"Oxford University Commences Human Trials for Nipah Virus Vaccine – A Promising Step in the Fight Against a Deadly Outbreak"

 On January 11, the University of Oxford shared that they've kicked off testing a new vaccine for the Nipah virus, which causes brain swelling and has led to outbreaks in India's Kerala state and other parts of Asia. Currently, there's no vaccine available for this deadly virus, which was first identified in Malaysia around 25 years ago and has caused outbreaks in Bangladesh, India, and Singapore.

The first group of people participating in the Oxford trial got their vaccine doses in the past week. This vaccine uses the same technology as the AstraZeneca and Serum Institute of India's COVID-19 shots. The initial stage of the trial involves 51 patients and will take place in Oxford. It aims to assess the safety and immune response of the vaccine in individuals aged 18 to 55, according to a spokesperson from the University's Pandemic Sciences Institute.

After this phase, more trials are anticipated in a country affected by Nipah. Dr. In-Kyu Yoon, an executive at the Coalition for Epidemic Preparedness Innovations (CEPI), emphasized the epidemic potential of Nipah, given that its fruit bat hosts are present in areas inhabited by over two billion people. This trial is viewed as a positive step in developing tools to safeguard against this dangerous virus.

The Oxford Vaccine Group is leading the trial, which is financially supported by CEPI—a global coalition dedicated to backing the development of vaccines for emerging infectious diseases. Moderna also initiated an early-stage clinical trial for a Nipah virus vaccine in 2022, collaborating with the U.S. National Institute of Allergy and Infectious Diseases.

Highlighting the urgency of the situation, in September, Kerala state in India experienced its fourth Nipah outbreak in five years, resulting in six infections and two deaths. The symptoms of Nipah infection include fever, headache, cough, and breathing difficulties, with a likelihood of brain swelling. The World Health Organization estimates its fatality rate to be between 40% and 75%.

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